Zambia swept aside Lesotho 4-0 to reclaim top spot in World Cup qualifying Group D from Ghana, who had moved to the summit on Friday after beating Sudan.
The 2012 African Champions have 10 points, one more than the Black Stars, after two goals from Jacob Mulenga and one each from Christopher Katongo and Collins Mbesuma earned them a comfortable win.
With two rounds of matches remaining it is now a straight fight between Chipolopolo and Ghana to finish top of the group and reach the play-offs as Sudan and Lesotho have been eliminated by their defeats this weekend.
Also out of the running to reach Brazil next year are Botswana, who fell 2-1 at home to Group A leaders Ethiopia.
Getaneh Kebede and Salahdin Ahmed put the visitors two goals up before half-time and, although Botswana hit back through Tebogo Sembowa, it was enough to earn the Walya Antelopes a victory that takes them to 10 points.
They lead South Africa by two points after Bafana Bafana also recorded a win in their game, away to Central African Republic (CAR).
Bernard Parker opened the scoring in the first half for the 2010 World Cup hosts and Siphiwe Tshabalala and Katlego Mashego added one apiece after the break to complete a 3-0 victory that keeps their qualification hopes alive.
CAR join Botswana in exiting the competition.
In group J, a fourth-minute goal from Tonny Mawejje proved sufficient to earn Uganda a win against Liberia in Kampala.
The result lifted The Cranes above the Lone Stars in the table, claiming second place by one point.